A rapid method for detecting the sickle cell trait

1 December 1945

journal article
research article
Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene

Vol. 39 (3) , 264
https://doi.org/10.1016/0035-9203(45)90027-7

Abstract

A drop of a saline or broth suspension from a 24- or 48-hr.-old Agar culture of Pseudomonas fluores-cens (bacteria) when added to a drop of blood from a suspect will cause a sickling of the red corpuscles within 5 mins. if the sickle cell trait is present. Within 15 mins. 70-90% of the corpuscles will be effected.

Keywords

ANEMIA/SICKLE CELL
ERYTHROCYTES/ELLIPTICAL