Precursor of cdk5 activator, the 23 kDa subunit of tau protein kinase II: Its sequence and developmental change in brain
- 21 November 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 355 (1) , 35-40
- https://doi.org/10.1016/0014-5793(94)01163-x
Abstract
Tau protein kinase II (TPKII) is shown by immunoprecipitation to be a complex composed of two subunits, a catalytic subunit, cdk5, and regulatory subunit, p23. By sequence analysis of p23 CDNA, p23 was found to occupy a region from the 99th amino acid residue to the C‐terminus of a novel protein with a molecular weight of 34,000 Da, suggesting that this 34 kDa protein is a precursor of p23 (pre‐p23). These findings suggest that p23 results from the processing of the precursor protein, pre‐p23. The precursor mRNA was expressed most abundantly in rat brain just before and after birth. Expression of pre‐p23, but not of cdk5, mRNA changed, coinciding with the developmental change of TPKII activity, suggesting that its expression controls the phosphorylation of tau by the TPKII/TPKI system in the neonatal brain. p23 appears to be a cdk5 activator in neuronal cells.Keywords
This publication has 28 references indexed in Scilit:
- Identification of the 23 kDa subunit of tau protein kinase II as a putative activator of cdk5 in bovine brainPublished by Wiley ,2001
- p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5Nature, 1994
- Localization and Developmental Changes of τ Protein Kinase I/Glycogen Synthase Kinase‐3β in Rat BrainJournal of Neurochemistry, 1994
- A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubuleFEBS Letters, 1993
- Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filamentsFEBS Letters, 1993
- Cyclins and cyclin-dependent kinases: take your partnersTrends in Biochemical Sciences, 1993
- τ Protein Kinase II Is Involved in the Regulation of the Normal Phosphorylation State of τ ProteinJournal of Neurochemistry, 1993
- D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNACell, 1992
- Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeastCell, 1991
- Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequenceCell, 1991