Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase
- 15 July 1999
- journal article
- Published by Springer Nature in Nature Cell Biology
- Vol. 1 (4) , 234-241
- https://doi.org/10.1038/12058
Abstract
In metazoans, certain calmodulin-related calcium-binding proteins (recoverins, neurocalcins and frequenins) are found at highest levels in excitable cells, but their physiological roles are largely uncharacterized. Here we show that Saccharomyces cerevisiae contains a frequenin homologue, Frq1, and that its target is Pik1, a phosphatidylinositol-4-OH kinase. Frq1 binds to a conserved sequence motif in Pik1 outside Pik1’s catalytic domain and stimulates its activity in vitro. N-myristoylated Frq1 may also assist in Pik1 localization.Keywords
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