Serum lipoprotein levels during chlorthalidone therapy. A Veterans Administration-National Heart, Lung, and Blood Institute cooperative study on antihypertensive therapy: mild hypertension

Publisher Website
Google Scholar
Abstract
In a joint Veterans Administration-National Heart, Lung and Blood Institute study of mild hypertension, 1012 men and women, 21-50 yr old with diastolic pressure from 85-105 mm Hg, were randomized into 2 double-blind treatment groups. Subjects in the active group received chlorthalidone or chlorthalidone plus reserpine, while the other subjects received matching placebo tablets. After 1 yr of treatment, the chlorthalidone group had increases of 10.0 .+-. 1.8 (SE) mg/dl in total cholesterol level, 9.8 .+-. 5.2 mg/dl in triglyceride level and 12.6 .+-. 3.4 mg/dl in low-density lipoprotein-cholesterol level above the changes in the placebo group. There was no difference in high-density lipoprotein changes between the 2 groups (0.1 .+-. 0.8 mg/dl). The possible net effect on risk of increasing lipid values while lowering pressure in the long-term treatment of mild hypertension with thiazides or related diuretics must be further evaluated.