PREPARATION OF CHIRAL AMINOPHOSPHINE LIGANDS AND THEIR USE IN ASYMMETRIC HOMOGENEOUS HYDROGENATION OF ITACONIC ACID
- 5 January 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 7 (1) , 3-6
- https://doi.org/10.1246/cl.1978.3
Abstract
Optically active aminophosphines were prepared via ortho-directed metalation of appropriate arylamines followed by introduction of a diphenylphosphino group. These aminophosphines were used as ligands in the rhodium complex-catalyzed asymmetric hydrogenation of itaconic acid. Although moderate optical yields (up to 43% ee) were obtained, the stereochemical outcome with each ligand depended markedly on the chelate effect of the aminophosphines which played a significant role in both catalytic activity and enantioselectivity.Keywords
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