Dendrotoxin-binding brain membrane protein displays a potassium channel activity that is stimulated by both cAMP-dependent and endogenous phosphorylations
- 25 July 1989
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 28 (15) , 6455-6460
- https://doi.org/10.1021/bi00441a044
Abstract
The purified protein that binds the K+ channel ligands dendroxtoxin I and mast cell degranulating peptide can be phosphorylated by cAMP-dependent protein kinase and by an endogenous protein kinase, which may be specific K+ channel kinase. Phosphorylations take place on the toxin-binding subunit, a polypeptide of 76-80 kDa. Phosphorylation by both kinases leads to activation of the reconstituted dendrotoxin-sensitive K+ channel.This publication has 2 references indexed in Scilit:
- Existence of different populations of the dendrotoxin I binding protein associated with neuronal K+ channelsBiochemical and Biophysical Research Communications, 1988
- Protein kinase associated with tubulin: affinity chromatography and propertiesBiochemistry, 1976