Gamma-Aminobutyric Acid Antagonism and Presynaptic Inhibition in the Frog Spinal Cord
- 21 January 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4019) , 331-333
- https://doi.org/10.1126/science.175.4019.331
Abstract
The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma-aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition.Keywords
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