Demonstration of Central Nervous Mediation of Acute Pulmonary Edema Produced by Intravenously Administered Epinephrine

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Abstract
Fifteen rats with severed spinal cords, kept alive on a respirator, were given massive doses of epinephrine that on controls produced consistently an intense acute pulmonary edema. None of these rats developed the usual acute edema, and in 10 cases the lungs had normal weight. This result is interpreted as a proof of the central nervous mediation of the acute pulmonary edema produced by administration of epinephrine.

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