The oxidation of polychlorinated benzenes by genetically engineered cytochrome P450cam: potential applications in bioremediation
- 31 January 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 3,p. 247-248
- https://doi.org/10.1039/a909536e
Abstract
Polychlorinated aromatic compounds are persistent environmental contaminants; we describe here the redesign and engineering of the haem monooxygenase cytochrome P450cam to oxidise these compounds efficiently to the chlorinated phenols which are readily degraded by many micro-organisms, thus providing a basis for novel systems for biological clean-up of these inert compounds.Keywords
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