CHLORPROMAZINE INHIBITS EPISODIC GROWTH HORMONE SECRETION IN THE RAT
- 1 July 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 91 (3) , 428-436
- https://doi.org/10.1530/acta.0.0910428
Abstract
Effects of chlorpromazine (CPZ) on plasma GH and prolactin levels were observed in conscious rats provided with chronic indwelling right atrial cannulae. The administration of CPZ (200 μg/100 g b.w. iv) suppressed episodic plasma GH burst and resulted in significant elevations of plasma prolactin levels. These were also observed in rats in which two types of hypothalamic deafferentation, i.e. anterior and complete, had been carried out. The data suggest that CPZ acts within the medial basal hypothalamus and inhibits episodic plasma GH secretion. In addition, it is inferred that catecholamines are involved in the generation of episodic plasma GH burst.This publication has 6 references indexed in Scilit:
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