The Nephrotic Syndrome as a Complication of Penicillamine Therapy for Hepatolenticular Degeneration (Wilson's Disease)

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Abstract
Penicillamine, an effective chelating agent for Cu, is frequently used in the treatment of Wilson''s Disease. A case is reported in which the administration of this drug initially led to a hypersensitivity reaction which was controlled by corticosteroids. Subsequent use of penicillamine resulted in the development of the nephrotic syndrome with massive albuminuria, hypoalbuminemia, edema, and hyperlipemia. Following cessation of penicillamine and the admistration of prednisone the albuminuria gradually decreased. Attention is called to the fact that this renal lesion, which is probably a hypersensitivity reaction, may complicate the treatment of Wilson''s Disease with penicillamine.

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