Differential Binding of 14C-Cortisone in Fetal, Placental, and Maternal Liver Tissue in A/Jax and C57BL Mice

Abstract
When 14C-cortisone was given to pregnant A/Jax and C57BL mice, the concentration of radioactivity firmly bound to fetal tissue was significantly higher in A/Jax mice than in C57BL mice. Differences in the binding of cortisone to tissue proteins may explain the differential incidences of cleft palate in A/Jax and C57BL mice.