Breakage of the T cell receptor ? chain locus in non malignant clones from patients with ataxia telangiectasia
- 1 August 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 79 (4) , 360-364
- https://doi.org/10.1007/bf00282177
Abstract
Patients with ataxia telangiectasia (A-T) develop specific chromosome translocations, which may confer a proliferative advantage, resulting in the appearance of large clones in the peripheral blood lymphocytes. These lymphocytes are not malignant. Using in situ hybridisation techniques we have investigated a consistent 14q11 translocation break-point observed in a t(X;14)(q28;q11) translocation clone from each of two different patients and a t(14;14)(q11;q32) clone from a third patient. In all cases the chromosome translocation involved breakage within the α chain locus of the T cell receptor (TCRα), between the variable and constant regions, at 14q11. Chromosome rearrangement involving breakage within TCRα can therefore precede the development of malignancy. Further chromosomal rearrangement may be required in these patients, for progression to the leukaemic state.This publication has 33 references indexed in Scilit:
- Growth of large chromosomally abnormal T cell clones in ataxia telangiectasia patients is associated with translocation at 14q11Human Genetics, 1987
- Alpha-chain locus of the T-cell antigen receptor is involved in the t(10;14) chromosome translocation of T-cell acute lymphocytic leukemia.Proceedings of the National Academy of Sciences, 1987
- T-cell receptor alpha-chain gene is split in a human T-cell leukemia cell line with a t(11;14)(p15;q11).Proceedings of the National Academy of Sciences, 1986
- The chromosome breakpoint at 14q32 in an ataxia telangiectasia t(14;14) T cell clone is different from the 14q32 breakpoint in Burkitts and an inv(14) T cell lymphomaHuman Genetics, 1986
- Fused transcript of abl and bcr genes in chronic myelogenous leukaemiaNature, 1985
- Location of Gene for β Subunit of Human T-Cell Receptor at Band 7q35, a Region Prone to Rearrangements in T CellsScience, 1985
- Common Region on Chromosome 14 in T-Cell Leukemia and LymphomaScience, 1984
- Localization of the human α-globin gene cluster to the short arm of chromosome 16 (16p12–16pter) by hybridization in situJournal of Molecular Biology, 1982
- Evolution of chromosomal abnormalities in sequential cytogenetic studies of ataxia telangiectasiaHuman Genetics, 1980
- High frequencies of inversions and translocations of chromosomes 7 and 14 in ataxia telangiectasiaMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980