Dosage Adjustment and Pharmacokinetic Profile of Irinotecan in Cancer Patients With Hepatic Dysfunction
- 1 November 2002
- journal article
- clinical trial
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 20 (21) , 4303-4312
- https://doi.org/10.1200/jco.2002.03.123
Abstract
PURPOSE: To determine the recommended dose (RD) and the pharmacokinetic profile of irinotecan and its metabolites in cancer patients with hyperbilirubinemia. PATIENTS AND METHODS: Patients were ass...Keywords
This publication has 15 references indexed in Scilit:
- Toxicity of irinotecan (CPT-11) and hepato-renal dysfunctionAnti-Cancer Drugs, 2001
- Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal CancerNew England Journal of Medicine, 2000
- Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphismClinical Pharmacology & Therapeutics, 1999
- Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancerThe Lancet, 1998
- Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancerThe Lancet, 1998
- Preclinical Antitumor Activity and Pharmacokinetics of Irinotecan (CPT‐11) in Tumor‐bearing MiceAnnals of the New York Academy of Sciences, 1996
- Relationship between the Pharmacokinetics of Irinotecan and Diarrhea during Combination Chemotherapy with CisplatinJapanese Journal of Cancer Research, 1995
- The structural basis of camptothecin interactions with human serum albumin: impact on drug stabilityJournal of Medicinal Chemistry, 1994
- Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11Japanese Journal of Cancer Research, 1993
- Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in cancer patientsJournal of Chromatography B: Biomedical Sciences and Applications, 1992