BIG GROWTH HORMONE(GH): CONVERSION TO SMALL GH WITHOUT PEPTIDE BOND CLEAVAGE

1 August 1975

journal article
other
Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism

Vol. 41 (2) , 422-425
https://doi.org/10.1210/jcem-41-2-422

Abstract

Mercaptoethanol treatment of big growth hormone (GH) obtained from human pituitary resulted in a 60% conversion to small GH. Further dissociation was obtained by combined treatment with the reducing agent plus urea. The results indicate that the existence of big GH is dependent upon the formation of inter-polypeptide chain disulfide bonds.

Keywords

DISULFIDE BONDS
SMALL GH
REDUCING AGENT
CONVERSION TO SMALL
BIG GROWTH HORMONE
UREA
PEPTIDE

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