Assessment of a radioisotopic assay for vitamin B12using an intrinsic factor preparation with R proteins blocked by vitamin B12analogues
- 1 October 1982
- journal article
- research article
- Published by BMJ in Journal of Clinical Pathology
- Vol. 35 (10) , 1110-1113
- https://doi.org/10.1136/jcp.35.10.1110
Abstract
A competitive protein binding radioassay kit for serum vitamin B12 was assessed. Precision, linearity, sensitivity, and specificity were satisfactory. Falsely-normal assay results in patients with vitamin B12 deficiency were not observed.Keywords
This publication has 11 references indexed in Scilit:
- A fault in the design of the deoxyuridine suppression testClinical and Laboratory Haematology, 2008
- Forms of vitamin B12 in radioisotope dilution assays.Journal of Clinical Pathology, 1981
- Comparison of serum vitamin B12 estimation by saturation analysis with intrinsic factor and with R-protein as binding agents.Journal of Clinical Pathology, 1981
- Use of an improved E. coli method for the measurement of cobalamin in serum: comparison with the E. gracilis assay results.Journal of Clinical Pathology, 1981
- Vitamin B12 quality control trials.1981
- CLINICAL-SIGNIFICANCE OF SERUM VITAMIN-B12 MEASURED BY RADIOASSAY USING PURE INTRINSIC-FACTOR1981
- Erroneously Low Results Due to High Nonspecific Binding Encountered with a Radioassay Kit That Measures “True” Serum Vitamin B12American Journal of Clinical Pathology, 1980
- Evidence That Some Patients with Pernicious Anemia Are Not Recognized by Radiodilution Assay for Cobalamin in SerumNew England Journal of Medicine, 1978
- Cobalamin Analogues Are Present in Human Plasma and Can Mask Cobalamin Deficiency because Current Radioisotope Dilution Assays Are Not Specific for True CobalaminNew England Journal of Medicine, 1978
- The Use of Chicken Serum for Measurement of Serum Vitamin B12Concentration by Radioisotope Dilution: Description of Method and Comparison with Microbiological Assay ResultsBritish Journal of Haematology, 1974