ASSESSMENT OF DRUG THERAPY WITH ASPIRIN, PREDNSOLONE, AND γ-GLOBULIN ALONE AND IN COMBINATION IN THE ACUTE STAGE OF KAWASAKI DISEASE

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Abstract
Although aspirin therapy or high-dose γ-globulin therapy may be effective in the acute stage of Kawasaki disease, there was a 12.8% incidence of coronary lesions in nationwide survey. We treated 269 patients in the acute stage with aspirin alone (group A, n=43), prednisolone plus aspirin (group B, n=157), high-dose γ-globulin plus aspirin (group C, n=24), and combination therapy consisting of aspirin, prednisolone and high-dose γ-globulin (group D, n=45) within 9 days of onset at Gunma Children's Medical Center and retrospectively reviewed the effects of the combination therapy in acute stage of Kawasaki disease. The incidence of coronary lesions greater than 4.0 mm was 9.3% in group A, 8.3% in group B, 16.7% in group C, and 2.2% in group D. The relatively small sample size in this study does not allow a more definitive statement, but combination therapy appears to be more effective for coronary lesions.

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