Processing of a Pseudorabies Virus-induced Protein which is Glycosylated, Sulphated and Excreted

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Abstract
Cells [BSC-1 African green monkey kidney] infected with pseudorabies virus excrete large amounts of a glycosylated sulfated protein, MW 89,000, into the extracellular fluid. The results of studies on the processing of this protein are reported. Glycosylation occurs during, or very soon after, synthesis of the polypeptide chain. After a delay of several minutes the glycoprotein is sulfated; inhibition of glycosylation by high concentrations of glucosamine does not interfere with this process. The glycosylated sulfated polypeptide is then reduced in size from MW 99,000 to 89,000, possibly by proteolytic cleavage, and is excreted. Inhibition of glycosylation does not interfere with the excretion of this polypeptide, which is an energy-requiring process.

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