THE REVERSIBILITY OF CANCER - EVIDENCE THAT MALIGNANCY IN HUMAN HEPATOMA-CELLS IS GAMMA-LINOLENIC ACID DEFICIENCY-DEPENDENT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 62  (19) , 683-685
Abstract
A critical test of Horrobin''s hypothesis that malignancy in cells may be dependent on deficiency of .gamma.-linolenic acid (GLA) a metabolic intermediary in the biosynthesis of prostaglandin E1, revealed that GLA supplementation produces a highly significant reduction in the growth rate (up to 87%) of a cultured human hepatoma cell line, compared with the growth rate of untreated hepatoma cells. This hypothesis requires urgent further investigation at all levels including trials in human cancer patients.