Long circulating, cationic liposomes containing amino‐PEG‐phosphatidylethanolamine
- 10 October 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 353 (1) , 71-74
- https://doi.org/10.1016/0014-5793(94)01013-7
Abstract
Ligand attachment to polyethylene glycol (PEG) grafted, long circulating liposomes at the polymer terminus is of interest for targeting but the effect of positively charged groups is unknown. Amino-polyethylene glycol-phosphatidylethanolamine (AminoPEG-PE), prepared in four steps from α-amino-ω-hydroxy-PEG, was tested for influence on liposome interactions in vivo: blood circulation and biodistribution. Despite surface amines on each liposome conferring cationic behavior, in vivo properties are comparable to those obtained with methoxy-PEG-PE. The consequences are profound for targeting and possibly systemic delivery of cationic lipidic-polynucleotide complexes.Keywords
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