Effects of Acute Vitamin Replacement Therapy on 6-aminonicotin-amide Induced Cleft Palate Late in Rat Pregnancy.

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Abstract
The present study was undertaken to test the ability of nicotinamide (NAM) to counteract the teratogenic effects of the niacin antimetabolite 6-aminonlcotinamide (6-AN). Cleft palate was selected as a model to study such niacin countertherapy. Pregnant rats were given single injections of NAM (8-100 mg/kg body wt) before or after a teratogenic dose of the vitamin antimetabolite 6-AN (8 mg/kg body wt) on day 15 of gestation. NAM effectively competed with 6-AN in preventing cleft palate when given 2 hrs. before, simultaneously, or up to 2 hrs. after antimetabolite treatment. However, vitamin replacement therapy was unable to prevent palatal abnormalities or restrict the action of 6-AN to specific time periods when given 12-24 hrs. before or 2-72 hrs. after 6-AN administration.