Knockout Corner: Knockout mice for monoamine oxidase A
Open Access
- 1 September 1999
- journal article
- Published by Oxford University Press (OUP) in International Journal of Neuropsychopharmacology
- Vol. 2 (3) , 241-243
- https://doi.org/10.1017/s1461145799001534
Abstract
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.Keywords
This publication has 0 references indexed in Scilit: