H1- and H2-Histamine Receptor Antagonists and Protection against Traumatic Shock

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Abstract
Pretreatment of mice with 4 different H1-receptor antagonists (i.e., diphenhydramine, promethazine, pyrilamine and pyribenzamine) exerted significant protection against Noble-Collip drum trauma (NCDT). Blockage of H2-receptors, however, was associated with an exacerbation of mortality after NCDT. Certain actions of histamine on H2-receptors may be beneficial in NCDT in mice, while actions on H1-receptors may be detrimental.