STUDIES WITH STAPHYLOCOCCAL TOXINS: VI. SOME PROPERTIES OF A NON-HEMOLYTIC DERMONECROTIC TOXIN PRODUCED BY SOME STRAINS OF STAPHYLOCOCCUS AUREUS

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Abstract
A non-hemolytic, dermonecrotic preparation with proteolytic activity was isolated from culture filtrates of some strains of Staphylococcus aureus using a chromatographic procedure with carboxymethyl-cellulose as a selective adsorbent. The preparation was resolved into components which were independently proteolytic and dermonecrotic using a zone electrophoresis procedure.The non-hemolytic dermonecrotic toxin possessed properties which characterize it as a protein. No relationship could be found between pathogenicity of the staphylococcus and its capacity to produce the toxin.The presence in some culture filtrates of the non-hemolytic, dermonecrotic toxin has been considered as a possible explanation for the lack of agreement noted by several authors between alpha hemolytic and dermonecrotic titers.

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