The Reaction of the Hydroxyl Radical with Glutathione in Neutral and Alkaline Aqueous Solution

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Abstract
The reaction of OH with glutathione (.gamma.-Glu-Cys-Gly) [GSH] in neutral and alkaline aqueous solutions was studied by pulse radiolysis. In addition to the S-centered GS.cntdot.(GSSG-.cntdot.) radical formed by electron transfer or H abstraction from GS- (GSH), at least 1 C-centered radical is formed with pH-dependent yield by H abstraction from the .gamma. C or the amino group on the .gamma.-glutamyl moiety. The latter radical is transformed in a first-order reaction most probably to a C-centered radical on the cysteine group. No evidence for the formation of C-centered radicals was found in comparable experiments with cysteine and 2-mercaptopropionylglycine.

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