The involvement of 5-hydroxytryptamine in the release of dendritic dopamine from slices of rat substantia nigra
- 1 November 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 35 (11) , 734-737
- https://doi.org/10.1111/j.2042-7158.1983.tb02880.x
Abstract
[3H]dopamine (DA) accumulated by slices of rat substantia nigra was released following superfusion with Krebs solution containing 5-hydroxytryptamine (5-HT) in a dose-dependent fashion with maximal release being produced by 1 × 104 m. This 5-HT-induced release of [3H]DA was calcium-dependent and was inhibited by pretreatment with the 5-HT antagonist cinanserin. These results are interpreted as supporting the possibility that 5-HT has a role in regulating dopaminergic activity in the nigro-striatal pathway.This publication has 21 references indexed in Scilit:
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