The Effects of Tianeptine and other Antidepressants on a Rat Model of Depression
- 1 February 1992
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 160 (S15) , 51-55
- https://doi.org/10.1192/s0007125000296682
Abstract
A model of depression based on measurements made after restraining rats for two hours has been developed. The model is associated with elevation in corticosterone, reflects the higher incidence of depression in women, and shows increased post-synaptic 5-HT function with adaptation. The effects of tianeptine and other antidepressants on the model were studied. Chronic pre-treatment with desipramine, sertraline (amine uptake inhibitors), and chlordiazepoxide normalised open field activity after restraint. Single high doses, post-restraint, of 8-OH-DPAT, gepirone (5-HT agonists), and tianeptine normalised open field activity, whereas desipramine, chlordiazepoxide, and diazepam did not. It is of considerable interest that tianeptine decreased the availability of 5-HT to receptors.Keywords
This publication has 31 references indexed in Scilit:
- A single dose of 8-OH-DPAT reduces raphe binding of [3H]8-OH-DPAT and increases the effect of raphe stimulation on 5-HT metabolismEuropean Journal of Pharmacology, 1990
- Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activityNeuropharmacology, 1989
- Adaptation of female rats to stress: shift to male pattern by inhibition of corticosterone synthesisBrain Research, 1988
- Modifications of the Serotonin System by Antidepressant TreatmentsJournal of Clinical Psychopharmacology, 1987
- Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like actionEuropean Journal of Pharmacology, 1987
- Life Events, Vulnerability and Onset of DepressionThe British Journal of Psychiatry, 1987
- Female rats are more vulnerable than males in an animal model of depression: the possible role of serotoninBrain Research, 1986
- Enhancement of some 5-HT-dependent behavioural responses following repeated immobilization in ratsBrain Research, 1985
- Low doses of the putative serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicit feeding in the ratPsychopharmacology, 1985
- Relationships in Healthy Volunteers Between Concentrations of Monoamine Metabolites in Cerebrospinal Fluid and Family History of Psychiatric MorbidityThe British Journal of Psychiatry, 1980