Recovery of Irradiated Bone Marrow Cells in Carbon-Treated Mice

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Abstract
The recovery of bone marrow cells irradiated in vitro and transplanted into RES-blockaded host mice was studied. Mice treated with carbon particles provided a favorable environmental effect on the recovery of irradiated spleen colony-forming cells. The shift of the survival curve of colony-forming units (CFU) in the carbon-treated mice was not due to an increase in the extrapolation number but to an apparent decrease in radiation sensitivity of the cells. The average weight of the spleen colony at day 10 did not exhibit any significant difference between experimental and control mice. The split-dose experiment revealed that there was no significant additional acceleration of the stem cell recovery although recovery of CFU was extensively enhanced by transplantation into the carbon-treated animals. RES-blockaded mice provide a favorable microenvironment for the recovery of hemopoietic stem cells after irradiation.

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