Studies of the Role of Fungi in Pulmonary Disease: I. Cross Reactions of Histoplasmin

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Abstract
Histoplasmin, blastomycin, coccidioidin, and haplosporangin were prepd. by procedures similar to those used in making coccidioidin. Cross reactions between the 4 antigens were demonstrated. A dilution of 1:100 of histoplasmin gave a positive reaction in guinea pigs with exptl. histoplasmosis, blastomycosis, coccidioidomycosis, and haplomycosis. 34 of 136 hospitalized persons reacted to both histoplasmin and blastomycin. The significance of the surprisingly high incidence of positive reactions to histoplasmin and blastomycin in man remains to be detd. We are not at present in a position to evaluate the clinical or epidemiological significance of these positive reactions as they occur singly or together, in view of the demonstrated cross reactions between these antigens.

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