Evaluation of an Automated Creatininase Creatinine Procedure
- 1 June 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 19 (6) , 623-625
- https://doi.org/10.1093/clinchem/19.6.623
Abstract
We have evaluated an automated method for determining serum creatinine by use of the enzyme creatininase. The method has been adapted to the Beckman DSA-560 and measures the Jaffé-positive chromogens present in serum before and after enzymatic hydrolysis of creatinine. The precision and linearity of the method are acceptable, and the results correlate well with those obtained by other accepted techniques. The method offers the advantages of automation, enhanced specificity, micro-scale sample volume, and direct serum analysis.Keywords
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