Reduction of Temperature and Lithium Poisoning

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To the Editor: Dysregulation of body temperature by lithium salts is a well-documented fact. The injection of lithium salts in rats and mice induces a hypothermic response1; most human beings treated with lithium have a consistently higher temperature than normal controls,2 and fever is a constant feature of poisoning during the semicomatose phase.3 To date, reduction of the central temperature or hypothermia has not been reported in cases of lithium overdose in human beings.In February 1985, a 74-year-old manic-depressive man, who had been operated on two weeks before for a gastric tumor, was transferred to our institution for . . .

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