Time-Course of Actinomycin D Inhibition of Tobacco Mosaic Virus Multiplication Relative to the Rate of Spread of the Infection

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Abstract
The time-course of inhibition of tobacco mosaic virus synthesis in mechanically inoculated leaves by actinomycin D was not correlated with cell-to-cell spread of the infection, as previously shown to be the case with 2-thiouracil and guanidine inhibition. The amount of inhibition by actinomyci¤ D declined after inoculation much more rapidly than the infection spread. An actinomycin-D-sensitive step or its product occurred in cells before they became infected.