PREGNANCY-SPECIFIC BETA-1 GLYCOPROTEIN AND CHORIONIC-GONADOTROPIN LEVELS FOLLOWING CONCEPTION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 26  (11) , 555-557
Abstract
Levels of pregnancy-specific .beta.1 glycoprotein (SP1) and .beta.-subunit human chorionic gonadotropin (.beta.-hCG) were measured in the plasma of 22 subjects in early pregnancy following spontaneous or induced ovulation. Minimum baseline levels for pregnancy detection were set at 4 .mu.g/l for SP1 and 15 IU/l for .beta.-hCG. Using these levels, in some cases SP1 was detectable by day 17 following ovulation and .beta.-hCG by day 13. All patients were diagnosed as pregnant by day 20 using SP1 and by day 18 using .beta.-hCG. Both placental proteins had similar doubling times in the plasma. There was no difference between pregnancies following spontaneous and induced ovulation. Until accurate normal ranges can be obtained, there will be problems of interpretation of levels near the limits of the sensitivities of the assay in clinical situations.

This publication has 0 references indexed in Scilit: