Improvement in Transdermal Bioavailability of Nitroglycerin by Formulation Design

Publisher Website
Google Scholar
Abstract
Controlled skin permeation kinetics of nitroglycerin [an antianginal drug] delivered by the 3 once-a-day transdermal therapeutic systems were recently evaluated and compared using the freshly excised hairless mouse abdominal skin mounted in a finite-dosing Frantz diffusion cell assembly. The kinetics of skin permeation from the convential ointment formulation was also studied using the same in vitro skin permeation system. Six experimental formulations of nitroglycerin were developed, aiming to enhance the permeation rate of nitroglycerin through intact skin. The kinetics of skin permeation of nitroglycerin from these experimental formulations was also investigated, using the same in vitro skin permeation system, and compared to the conventional ointment formulations as well as the newly marketed once-a-day transdermal therapeutic systems. Evidently the rates of skin permeation can be greatly improved by proper formulation design.