PLASMA LEVELS OF GROWTH HORMONE IN PATIENTS WITH DIABETES MELLITUS, HYPERCHOLESTEROLAEMIA AND LIVER DISEASES

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Abstract
From the plasma of 30 out of 51 patients with various metabolic disorders a »growth-hormone-like« factor was concentrated which when injected into hypophysectomized rats increased the width of the tibial epiphysis. A similar factor had previously been concentrated from the plasma of acromegalic patients. It was tentatively concluded that this factor was identical with human growth hormone (HGH). Diabetes mellitus. Of 40 patients with diabetes mellitus 24 showed elevated plasma levels of human growth hormone (HGH). The frequency of elevated plasma levels was higher in young diabetics than in older diabetic patients; in many cases a nondiabetic complication was associated with an elevated level. In the plasma of 4 patients with diabetes mellitus and liver diseases an elevated plasma level of HGH was found while in 3 patients with Kimmelstiel-Wilson's syndrome no increase of HGH was found. Liver diseases. In the plasma of 4 patients with various liver diseases an elevated plasma level of HGH was found while in the plasma of another 4 patients no increase of HGH was found. Hypercholesterolaemia. In the plasma of 2 patients with familiar hypercholesterolaemia elevated levels of HGH was found while no HGH was found in a patient with an idiopathic type of the disease.

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