Sodium nitroprusside degenerates cultured rat striatal neurons
- 1 March 1991
- journal article
- molecular neuroscience
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 2 (3) , 121-123
- https://doi.org/10.1097/00001756-199103000-00002
Abstract
Incubation of a primary culture of rat striatal neurons with sodium nitroprusside (SNP), a known source of nitric oxide (NO), showed a concentration-dependent increase in cyclic GMP levels with an EC50 value of 13.7 μM. Twenty-four hours following incubation with 10 μM SNP, striatal neurons underwent degeneration as assessed immunohistochemically and biochemically. In contrast, potassium ferricyanate at concentrations up to 1 mM had no effect on striatal neuron viability. These results indicate that SNP has neurotoxic actions in-vitro, an effect that may involve NO as a second messenger.Keywords
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