Crystal and molecular structure of tamaulipin-A, a trans,trans-germacra-1(10),4-dienolide sesquiterpene lactone
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 3,p. 204-208
- https://doi.org/10.1039/p29780000204
Abstract
The crystal and molecular structure of tamaulipin-A (I), C15H20O3, has been determined by single-crystal X-ray diffraction. Crystals are orthorhombic, space group P212121, a= 7.890(9), b= 11.957(13), c= 14.649(17)Å, Z= 4. The structure was solved from diffractometer data by direct phasing techniques and refined by full-matrix least-squares to R 8.1% over 732 reflections. The cyclodecadiene ring is in the chair–chair conformation, the methyl groups attached to C(4) and C(10) are in the syn-β-orientation (absolute configuration inferred from independent data), and the α-methylene-γ-lactone is trans-fused at C(6) and C(7) with H(6)β and H(7)α. Weak intermolecular hydrogen bonds exist between the hydroxy-group at C(2) and the lactone carbonyl [H ⋯ O 2.2(1), O ⋯ O 3.00(1)Å].Keywords
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