Malignant Tumors in Rats Fed Nafenopin, a Hepatic Peroxisome Proliferator 2
- 1 December 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 59 (6) , 1645-1650
- https://doi.org/10.1093/jnci/59.6.1645
Abstract
Nafenopin (2-methyl-2-[P-(1 ,2,3,4-tetrahydro-1-naphthyl) phenoxy] propionic acid; Su-13,437), a potent hypolipidemic hepatic peroxisome proliferator, was fed to male F344 rats at a dietary concentration of 0.1% until the end of the experiment at 25 months. Between 18 and 25 months, 12 of 15 rats (80%) developed tumors. Approximately 73% (11/15) developed hepatocellular carcinomas, and 20% (3/15) developed pancreatic aclnar cell tumors, including 1 metastasizing carcinoma. The hepatocellular carcinomas as weil as the acinar cell carcinoma of the pancreas were transplantable successfully through 6 generations.Keywords
This publication has 1 reference indexed in Scilit:
- A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.Proceedings of the National Academy of Sciences, 1976