A comparative study of Dextran 70 and a sulphated polysaccharide in the prevention of postoperative thromboembolic complications

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Abstract
A prospective randomized study has been performed, comparing a semisynthetic polysulphated xylan of vegetable origin (mol. wt ˜ 4000) with Dextran 70 as prophylactic agent against postoperative thromboembolic complications following elective abdominal surgery. A total of 109 patients entered the trial and the analysis after exclusions is based on 86 patients. The overall frequency of125 I ‐labelled fibrinogen test‐detected thrombosis was 2·9 per cent in the polysaccharide group against 19·2 per cent in the Dextran 70 group (P < 0·05). There was no difference in haemorrhage or different complications.
Funding Information
  • University of Lund
  • Swedish Medical Research Council (B80–17X-00759–15A)
  • Pharmacia AB