Study of Phosphate Excretion by the Stop-Flow Technique

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Abstract
The stop-flow technique has been applied to the dog in an attempt to rule out tubular secretion of phosphate and to locate the site of action of parathyroid hormone (PTH) on the renal tubule. Under the experimental conditions used, no significant inward transtubular movement of P32 could be demonstrated, ruling out tubular secretion of phosphate. Stop-flow experiments performed in parathyroidectomized dogs before and after PTH administration demonstrated inhibition of phosphorus reabsorption by the hormone. In addition, the stop-flow pattern indicated that this phenomenon took place mainly in the distal part of the proximal tubules.