Two haplotypes of the P2X7receptor containing the Ala‐348 to Thr polymorphism exhibit a gain‐of‐function effect and enhanced interleukin‐1β secretion
Open Access
- 7 April 2010
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 24 (8) , 2916-2927
- https://doi.org/10.1096/fj.09-150862
Abstract
The P2X7 receptor is an ATP-gated cation channel expressed in immune cells and plays a role in proinflammatory cytokine release from monocytes and macrophages. This study investigated the coinheritan...Keywords
Funding Information
- National Health and Medical Research Council
- Cure Cancer Australia Foundation
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