Studies on the Mode of Action of Somatostatin on Insulin Secretion

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Abstract
The effect of somatostatin on insulin release by incubated slices of rat pancreas was studied. Somatostatin inhibited insulin release induced by arginine/glucose (A/G), glucagon, glibenclamide, pentoxifyllin, (c[cyclic]AMP), phenotolamine and KCl. When A/G was used as a stimulus, the quantal inhibitory effect of somatostatin was not neutralized by progressively increasing glucose concentrations. The .alpha. adrenergic blocking agent phentolamine, the phosphodiesterase inhibitors theophylline (10 mM) or pentoxifyllin (10 mM), and KCl partially reversed the inhibitory effect of somatostatin on A/G stimulation. The maximal reversal of somatostatin inhibition was obtained when the slices of pancreas were stimulated with A/G in the presence of the calcium ionophore A23187 plus ATP. These results suggest that the inhibitory effect of somatostatin on insulin secretion could result from Ca translocation in pancreatic .beta. cells.

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