The Hemodynamic Response to Lanatoside C of Dogs with Experimental Aortic-Caval Fistulas

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Abstract
Dogs were prepared with a chronic aortic-caval fistula. At the time of study, performance of the left ventricle was characterized by a high level of left ventricular end-diastolic pressure, cardiac output, stroke volume, and stroke work, and in most instances with one of more evidences indicative of cardiac failure such as pulmonary edema, edema of the extremities, and ascites. After a period varying from one to 14 months, the dogs were digitalized rapidly with Lanatoside C and the hemodynamic effects were observed during the next hour and in some animals after four days of maintenance dosage on digitoxin. Measurements of various cardio-dynamic parameters indicated that digitoxin did not alter measurably the cardiac performance.