HEMOCHROMATOSIS

9 December 1933

journal article
research article
Published by American Medical Association (AMA) in JAMA

Vol. 101 (24) , 1874-1876
https://doi.org/10.1001/jama.1933.02740490034009

Abstract

Hemochromatosis is a chronic disease characterized by the presence of large quantities of hemofuscin and hemosiderin in the tissues, particularly in the liver and pancreas. The iron in this pigment is apparently of both endogenous and exogenous origin. The exact mechanism of this dysfunction of iron metabolism is, as yet, not known. Mallory¹has produced a pigment cirrhosis of the liver in animals by means of the prolonged administration of copper salts and also finely divided metallic copper. In a large number of human cases there has been a history of chronic copper poisoning either through occupational contact or through the prolonged ingestion of beverages or foods containing copper. The following case has been under observation for almost six years, during which time some interesting features have been observed, particularly those associated with the diabetic manifestations: REPORT OF CASE A white man, aged 42, single, a cabinet maker, admitted

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