Factors Influencing Morbidity and Mortality in Infants with Severe Respiratory Distress Syndrome Treated with Single or Multiple Doses of a Natural Porcine Surfactant
- 1 January 1992
- journal article
- clinical trial
- Published by S. Karger AG in Neonatology
- Vol. 61 (Suppl. 1) , 26-30
- https://doi.org/10.1159/000243840
Abstract
In an international multicenter trial infants with clinical and radiological signs of severe RDS (age 2-15 h, birthweight 700-2,000 g, mechanical ventilation, FiO2 ≧ 0.6, no complicating disease) were randomized to receive either a single dose (n = 176) or up to three subsequent doses (n = 167) of a natural porcine surfactant (Curosurf). Using a logistic regression model, the effects of therapy, birthweight, sex, hospital and other clinical factors on survival and various outcome parameters were evaluated. Mortality (13 vs. 21 %, p < 0.05) and the incidence of pneumothorax (9 vs. 18%, p < 0.01) were significantly lower in the multiple-dose group. Low birthweight, hospital allocation, low Apgar score and initial disease severity were associated with an increased mortality. Low birthweight, hypothermia (admission temperature < 36°C) and acidosis (pH < 7.25) prior to surfactant treatment could be identified as risk factors for the development of intracranial hemorrhage.Keywords
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