THE FORMATION OF HYDROXYTYRAMINE BY EXTRACTS OF RENAL CORTEX AND BY PERFUSED KIDNEYS

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Abstract
A pressor substance, presumably hydroxytyramine, was produced by the anaerobic incubation of renal cortical extracts of the guinea pig with dopa (l-dihydroxyphenylalanme) and by the perfusion of the isolated kidney of the cat with dopa. In the incubation expts. the activity of the dopa de-carboxylase responsible for the transformation of dopa into hydroxytyramine was inhibited by Oa, provided that the amt. of dopa used did not exceed the capacity of the oxidizing enzyme. In the perfusion expts., in which the kidney was perfused through the renal artery with blood containing dopa, it was evident that the amt. of hydroxytyramine produced varied inversely with the rate of blood flow through that organ. Blood incubated with dopa under N, and liver and gut of the cat perfused under reduced flow with blood containing dopa were not able to form the pressor substance.

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