Effect of Aureomycin on Viruses of the Psittacosis-LGV Group in Embryonated Eggs and Mice

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Abstract
Aureomycin was effective, in both embryo- 17715-17723 CHEMOTHERAPY [Vol. 25] 1622 nated eggs and in mice, in controlling exptl. infections with 10 strains of virus in the psittacosis-lymphogranuloma venereum group. Drug activity was evidenced in both the comparative titers of treated and untreated embryos, and in the titer of the virus recovered from these treated embryos. In mice, multiple doses of 0-5 mg. of drug lengthened significantly the life span of treated groups of animals (Borg, S-F, Gleason, 6BC, P-207), as compared to untreated controls. Gradations in these therapeutic effects were demonstrated by lesser amts. of drug. The survival of treated mice as compared to untreated controls was markedly increased by repeated cycles of drug treatment.

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