ACIDIC URINARY METABOLITES OF PROGESTERONE: STUDIES ON THE PREGNANT RABBIT

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Abstract
SUMMARY Indirect evidence is presented which suggests that the same acidic metabolites are obtained from the hydrolysed urine of the pregnant rabbit as from the non-pregnant animal injected with labelled progesterone. The acidic urinary metabolites were characterized by conversion with borohydridebismuthate to neutral aldehydes, which were then chromatographed on SE-30 and QF-1. In four rabbits the urinary excretion of the aldehydogenic metabolites and of pregnanediol, before and after mating, was parallel; the highest values were obtained in the 24 hr. after the coital stimulus.

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