EFFECT OF HYDROCORTISONE ON LONG‐TERM HUMAN MARROW CULTURES

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Abstract
Summary.: In human long‐term marrow cultures a relatively high concentration of hydrocortisone (10−6 M or more) is necessary for the development and subsequent maintenance of some cellular components in the adherent cell layer. However, such concentrations of hydrocortisone seem to be inhibitory for the production of granulocyte/macrophage progenitor cells (GM‐CFC). In further attempts to improve these cultures, therefore, it is important to maintain a balance between a concentration of hydrocortisone which is necessary for the development of a competent adherent layer and the concentration which is inhibitory to the production of GM‐CFC.

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