The antimicrobial activity of cefpirome, a new cephalosporin

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Abstract
The activity of the extended spectrum cephalosponn cefpirome (HR 810) was compared with that of other /Mactams and gentamicin. A total of 524 clinical isolates and strains known to be resistant to certain agents were studied. Against the Enterobactenaceae, Haemophilus influenzae and Neisseria spp. cefpirome was highly active (MIC9O≤0.5mg/l), generally being as active or slightly more active than ceftazidime and cefotaxime, and 8 to 32 times more active than cefuroxime. Against Pseudomonas aeruginosa cefpirome (MIC90 8mg/l) was four-fold less active than ceftazidime.Staphylococcus aureus was susceptible to cefpirome (MIC90 2mg/l) and cefpirome was the only cephalosporin tested with significant activity against Lancefield Group D streptococci.Bacteroides spp. (with the exception of Bactureolyticus) were resistant to cefpirome. The compound was bactericidal to all the susceptible strains studied with the exception of Lancefield Group D streptococci. The major target site for cefpirome was PBP 3 and the protein binding was low.